This manuscript presents a replication-oriented reassessment of the published evidence reported in Genes and Sales [1]. The study examines whether salespeople’s genetic variants linked to educational attainment predict objective sales performance in a telemarketing setting and, more importantly, whether the reported empirical pattern remains credible once its motivation, inferential limits, and behavioral mechanisms are stated with greater precision. Using a 13-month panel of 117 salespeople and 1,053 salesperson-month observations, the published analysis shows that the educational-attainment polygenic score is positively associated with daily sales revenue. This relationship remains statistically significant after controlling for demographic characteristics, task tier, principal components for population stratification, and actual educational attainment. The reported evidence is further strengthened by validation exercises already documented in the source study, including alternative score constructions, falsification tests, and joint models that incorporate selling effort and the Big Five personality traits. Mechanism analyses indicate that adaptive learning-related skills, operationalized through customer orientation and opportunity recognition, partially explain the gene–sales association. The evidence therefore supports a disciplined conclusion that both relatively stable endowments and more malleable behavioral inputs matter for sales outcomes, while also requiring careful interpretation because the reported estimates are conditional associations in a repeated-observation panel rather than deterministic or causal effects. The manuscript closes by identifying the most consequential next step for the literature: formally testing nonlinear effects and task-contingent person–job fit through re-estimation with the supplemental data files rather than inference from the PDF alone.